
                                SEQUENCE LISTING

<110> Trimeris, Inc.

<120> Dosing Regimens and Dosage Formulations
  of an Antiviral Peptide Therapeutic
  

<130> 7872-143-228

<140>
<141> 2009-10-22

<150> 61/108,048          
<151> 2008-10-24  

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> T144 (Tri-1144) synthetic 38 amino acid peptide
      derived from the HIV gp41 sequence

<400> 1
Thr Thr Trp Glu Ala Trp Asp Arg Ala Ile Ala Glu Tyr Ala Ala Arg
 1               5                  10                  15      
Ile Glu Ala Leu Leu Arg Ala Leu Gln Glu Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Ala Ala Leu Arg Glu Leu
        35              


<210> 2
<211> 57
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heptad repeat 1 (HR1) of HIV-1 gp41 sequence

<400> 2
Thr Leu Thr Val Gln Ala Arg Leu Leu Ser Gly Ile Val Gln Gln Gln
 1               5                  10                  15      
Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu
            20                  25                  30          
Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu
        35                  40                  45              
Arg Tyr Leu Lys Asp Gln Gln Leu Leu
    50                  55          


<210> 3
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heptad repeat 2 (HR2) of HIV-1 gp41 sequence

<400> 3
Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn Asn
 1               5                  10                  15      
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
            20                  25                  30          
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
        35                  40                  45              
Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe
    50                  55                  60                  


<210> 4
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Natural Amino Acid Sequence contained within the
      HR2 region of HIV-1 gp41

<400> 4
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 5
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> NL4-3 isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 5
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 6
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> LaV1a isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 6
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 7
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> IIIB isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 7
Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 8
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> HXB2 isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 8
Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 9
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> DH12 isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 9
Met Thr Trp Met Gln Trp Glu Lys Glu Ile Asn Asn Tyr Thr Gly Leu
 1               5                  10                  15      
Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 10
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> BRU isolate contained within the HR2 region of teh
      HIV-1 gp41 region

<400> 10
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 11
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> HXB2 isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 11
Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 12
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> pNL4-3 isolate contained within the HR2 region of
      teh HIV-1 gp41 region

<400> 12
Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu
 1               5                  10                  15      
Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 13
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ug273-A isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 13
Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Ile
 1               5                  10                  15      
Ile Tyr Asp Leu Ile Glu Glu Ala Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Asp Leu Leu
        35      


<210> 14
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> US2-B isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 14
Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Thr
 1               5                  10                  15      
Ile Tyr Thr Leu Leu Glu Glu Ser Gln Leu Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 15
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ug268-C isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 15
Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr
 1               5                  10                  15      
Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Lys Asp Leu Leu
        35      


<210> 16
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Se365-D isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 16
Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu
 1               5                  10                  15      
Ile Tyr Ser Leu Ile Glu Glu Ser Gln Thr Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 17
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> CM240-E isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 17
Met Thr Trp Ile Glu Trp Glu Arg Glu Ile Ser Asn Tyr Thr Asn Gln
 1               5                  10                  15      
Ile Tyr Glu Ile Leu Thr Glu Ser Gln Asn Gln Gln Asp Arg Asn Glu
            20                  25                  30          
Lys Asp Leu Leu
        35      


<210> 18
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Bz126-F isolate contained within the HR2 region of
      HIV-1 gp41 sequence

<400> 18
Met Thr Trp Met Glu Trp Glu Lys Glu Ile Ser Asn Tyr Ser Tyr Glu
 1               5                  10                  15      
Ile Tyr Arg Leu Ile Glu Gln Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Glu Leu Leu
        35      


<210> 19
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> HH8793-G isolate contained within the HR2 region
      of HIV-1 gp41 sequence

<400> 19
Met Thr Trp Ile Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gln Gln
 1               5                  10                  15      
Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu
            20                  25                  30          
Gln Asp Leu Leu
        35      

